PubMed
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
Richie et al., 2015
Longevity & Anti-AgingClinical / CompoundableC
Glutathione
GSH
Endogenous tripeptide antioxidant used across wellness and clinical protocols.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 5
- Research grade
- C
- Experience
- 99
- Activity
- 35
Overall check-ins
Trackers & reports
Overview
About Glutathione
Endogenous tripeptide antioxidant used across wellness and clinical protocols.
- Category
- Longevity & Anti-Aging
- Regulatory status
- Clinical / Compoundable
- Also known as
- GSH
- Self-reports
- 37
Community
What 37 users report
37 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 98% · Mixed 2% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Mood
134
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Digestive upset
3
Self-reported dose per injection
Median bucket: 5+ mg · Most common: 5+ mg
Reports span 0.2 to ≥ 5 mg (open-ended top bucket)
0.2–0.4 mg
1
0.4–0.6 mg
1
1–2 mg
10
2–3 mg
3
5+ mg
119
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 96% said they felt similar to their last entry, 4% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 66 days · Based on 26 repeat reporters
Research
Cited research (4)
Source
PubMed
Intravenous glutathione for skin lightening: Inadequate safety data
Davids et al., 2016
PubMed
Dietary glutathione supplementation enhances antioxidant activity and protects against lipopolysaccharide-induced acute hepatopancreatic injury and cell apoptosis in Chinese mitten crab, Eriocheir sinensis
Liu et al., 2020
PubMed
Glutathione and Selenium Supplementation Attenuates Liver Injury in Diethylnitrosamine-Induced Hepatocarcinogenic Mice by Enhancing Glutathione-Related Antioxidant Capacities
Hsiao et al., 2024
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Frequently asked
What do PeptIQ users report about Glutathione?
This page summarizes 37 anonymized self-reports from PeptIQ users who track Glutathione, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for Glutathione?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for Glutathione?
4 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is Glutathione safe to use?
This wiki does not assess safety or recommend use. Glutathione is listed as Clinical / Compoundable. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of Glutathione?
Research, primarily in animal models, suggests Glutathione may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of Glutathione?
Glutathione is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Glutathione as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of Glutathione?
The safety and effectiveness of Glutathione have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on Glutathione?
While there are over 200 published studies on Glutathione, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source