PubMed
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias et al., 2021
Longevity & Anti-AgingSupplement / Clinical UseS
NAD+
Nicotinamide Adenine Dinucleotide
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme present in all living cells, central to energy metabolism (cellular respiration), DNA repair, and sirtuins-mediated gene expression regulation. NAD+ levels decline significantly with aging. IV and subcutaneous NAD+ infusion clinics have grown substantially for anti-aging, metabolic health, cognitive support, and addiction recovery. Oral precursors (NMN, NR) are widely available as supplements.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 10
- Research grade
- S
- Experience
- 56
- Activity
- 79
Overall check-ins
Trackers & reports
Overview
About NAD+
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme present in all living cells, central to energy metabolism (cellular respiration), DNA repair, and sirtuins-mediated gene expression regulation. NAD+ levels decline significantly with aging. IV and subcutaneous NAD+ infusion clinics have grown substantially for anti-aging, metabolic health, cognitive support, and addiction recovery. Oral precursors (NMN, NR) are widely available as supplements.
- Category
- Longevity & Anti-Aging
- Regulatory status
- Supplement / Clinical Use
- Also known as
- Nicotinamide Adenine Dinucleotide
- Self-reports
- 96
Community
What 96 users report
96 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 2% · Mixed 98% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
197
Appetite
197
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Headache
66
Nausea
64
Injection site irritation
64
Self-reported dose per injection
Median bucket: 5+ mg · Most common: 5+ mg
Reports span 0.1 to ≥ 5 mg (open-ended top bucket)
0.1–0.2 mg
2
0.2–0.4 mg
17
0.4–0.6 mg
8
0.6–1 mg
1
1–2 mg
2
3–5 mg
2
5+ mg
165
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 95% said they felt similar to their last entry, 5% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 51 days · Based on 42 repeat reporters
Research
Cited research (8)
Source
PubMed
Safety and efficacy of NAD+ supplementation: a systematic review
Reiten et al., 2021
PubMed
NAD+ intermediates: The biology and therapeutic potential
Yoshino et al., 2018
ClinicalTrials.gov
NAD+ studies on ClinicalTrials.gov
ClinicalTrials.gov, 2024
PubMed
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Bhasin et al., 2023
PubMed
NAD⁺ in aging, metabolism, and neurodegeneration
Verdin, 2015
PubMed
NAD+ and sirtuins in aging and disease
Imai et al., 2014
PubMed
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song et al., 2023
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Frequently asked
What do PeptIQ users report about NAD+?
This page summarizes 96 anonymized self-reports from PeptIQ users who track NAD+, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for NAD+?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for NAD+?
8 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is NAD+ safe to use?
This wiki does not assess safety or recommend use. NAD+ is listed as Supplement / Clinical Use. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of NAD+?
Research, primarily in animal models, suggests NAD+ may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of NAD+?
NAD+ is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified NAD+ as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of NAD+?
The safety and effectiveness of NAD+ have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on NAD+?
While there are over 200 published studies on NAD+, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source