PubMed
Stable gastric pentadecapeptide BPC 157: Novel therapy in gastrointestinal tract
Sikiric P, Seiwerth S, Rucman R, et al. Curr Pharm Des. 2018
Healing & RecoveryResearch OnlyS
BPC-157
Pentadecapeptide BPC 157
BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a gastric juice protein, researched extensively for accelerating tissue healing, gut repair, and tendon recovery. Animal studies demonstrate dose-dependent healing of tendons, ligaments, bones, muscles, and intestinal tissue, along with anti-inflammatory and angiogenic effects. Not FDA-approved; placed on the FDA's 503A prohibited bulk substances list in 2023.
Last reviewed . First published . By the PeptIQ team.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 14
- Research grade
- S
- Experience
- 99
- Activity
- 70
Overall check-ins
Trackers & reports
Overview
About BPC-157
BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a gastric juice protein, researched extensively for accelerating tissue healing, gut repair, and tendon recovery. Animal studies demonstrate dose-dependent healing of tendons, ligaments, bones, muscles, and intestinal tissue, along with anti-inflammatory and angiogenic effects. Not FDA-approved; placed on the FDA's 503A prohibited bulk substances list in 2023.
- Category
- Healing & Recovery
- Regulatory status
- Research Only
- Also known as
- Pentadecapeptide BPC 157
- Self-reports
- 128
Community
What 128 users report
128 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 98% · Mixed 2% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Recovery
247
Energy
2
Sleep
1
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Nausea
5
Inflammation
1
Self-reported dose per injection
Median bucket: 0.2–0.4 mg · Most common: 0.2–0.4 mg
Reports span 0 to ≥ 5 mg (open-ended top bucket)
0–0.01 mg
2
0.025–0.05 mg
1
0.1–0.2 mg
3
0.2–0.4 mg
138
0.4–0.6 mg
94
0.6–1 mg
5
1–2 mg
1
3–5 mg
1
5+ mg
1
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 94% said they felt similar to their last entry, 6% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 50 days · Based on 47 repeat reporters
Research
Sources (10)
- Wiki study page →Source
- Wiki study page →Source
PubMed
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
Chang CH, Tsai WC, Lin MS, et al. Molecules. 2019
- Wiki study page →Source
PubMed
BPC 157 and its role in accelerating wound healing
Vukojevic J, Siroglavic M, Kasnik K, et al. Int J Mol Sci. 2022
- Wiki study page →Source
ClinicalTrials.gov
BPC-157 studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing
Seiwerth S, Rucman R, Turkovic B, et al. Current pharmaceutical design. 2018
- Wiki study page →Source
PubMed
Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions
Ilic S, Drmic D, Franjic S, et al. Life sciences. 2011
- Wiki study page →Source
PubMed
Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain
Lee E, Padgett B. Altern Ther Health Med. 2021
- Wiki study page →Source
PubMed
From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management
Yuan C, Demers A, Silva-Ortiz V, et al. Int J Mol Sci. 2026
- Wiki study page →Source
PubMed
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK, Bolia IK, Feingold CL, et al. Am J Sports Med. 2026
- Wiki study page →Source
PubMed
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF, Lee SJ, Seeds WA. JAAOS Glob Res Rev. 2026
Tools
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Frequently asked
What do PeptIQ users report about BPC-157?
This page summarizes 128 anonymized self-reports from PeptIQ users who track BPC-157, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for BPC-157?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for BPC-157?
10 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is BPC-157 safe to use?
This wiki does not assess safety or recommend use. BPC-157 is listed as Research Only. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of BPC-157?
This wiki summarizes observational community reports and linked citations for BPC-157. It does not assert therapeutic benefits. See the sources list on this page and the educational profile for BPC-157 for study-level context — not medical advice.
What is the legal status of BPC-157?
BPC-157 is listed in PeptIQ as Research Only. Regulatory status varies by jurisdiction and can change. This wiki does not provide legal advice; check current FDA and local rules and talk with a licensed clinician or counsel for personal decisions.
What are the known or theoretical side effects and risks of BPC-157?
Safety data quality for BPC-157 varies widely by compound and study design. PeptIQ does not establish a risk profile here. Review primary literature, product labeling where applicable, and clinician guidance. Community self-reports are not a substitute for clinical evidence.
What is the current state of research on BPC-157?
This page links 10 sources for BPC-157. Evidence maturity differs by application — some peptides have large human programs, others are mostly preclinical. Treat citation counts as literature volume, not proof of efficacy.