PubMed
Stable gastric pentadecapeptide BPC 157: Novel therapy in gastrointestinal tract
Sikiric et al., 2018
Healing & RecoveryResearch OnlyS
BPC-157
Pentadecapeptide BPC 157
BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a gastric juice protein, researched extensively for accelerating tissue healing, gut repair, and tendon recovery. Animal studies demonstrate dose-dependent healing of tendons, ligaments, bones, muscles, and intestinal tissue, along with anti-inflammatory and angiogenic effects. Not FDA-approved; placed on the FDA's 503A prohibited bulk substances list in 2023.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 14
- Research grade
- S
- Experience
- 99
- Activity
- 70
Overall check-ins
Trackers & reports
Overview
About BPC-157
BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a gastric juice protein, researched extensively for accelerating tissue healing, gut repair, and tendon recovery. Animal studies demonstrate dose-dependent healing of tendons, ligaments, bones, muscles, and intestinal tissue, along with anti-inflammatory and angiogenic effects. Not FDA-approved; placed on the FDA's 503A prohibited bulk substances list in 2023.
- Category
- Healing & Recovery
- Regulatory status
- Research Only
- Also known as
- Pentadecapeptide BPC 157
- Self-reports
- 126
Community
What 126 users report
126 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 98% · Mixed 2% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Recovery
245
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Nausea
5
Self-reported dose per injection
Median bucket: 0.2–0.4 mg · Most common: 0.2–0.4 mg
Reports span 0 to ≥ 5 mg (open-ended top bucket)
0–0.01 mg
2
0.025–0.05 mg
1
0.1–0.2 mg
3
0.2–0.4 mg
138
0.4–0.6 mg
93
0.6–1 mg
5
1–2 mg
1
3–5 mg
1
5+ mg
1
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 94% said they felt similar to their last entry, 6% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 50 days · Based on 47 repeat reporters
Research
Cited research (10)
Source
PubMed
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
Chang et al., 2019
PubMed
BPC 157 and its role in accelerating wound healing
Vukojevic et al., 2022
ClinicalTrials.gov
BPC-157 studies on ClinicalTrials.gov
ClinicalTrials.gov, 2024
PubMed
BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing
Seiwerth et al., 2018
PubMed
Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions
Ilic et al., 2011
PubMed
Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain
Lee et al., 2021
PubMed
From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management
Yuan et al., 2026
PubMed
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield et al., 2026
PubMed
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman et al., 2026
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Frequently asked
What do PeptIQ users report about BPC-157?
This page summarizes 126 anonymized self-reports from PeptIQ users who track BPC-157, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for BPC-157?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for BPC-157?
10 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is BPC-157 safe to use?
This wiki does not assess safety or recommend use. BPC-157 is listed as Research Only. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of BPC-157?
Research, primarily in animal models, suggests BPC-157 may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of BPC-157?
BPC-157 is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified BPC-157 as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of BPC-157?
The safety and effectiveness of BPC-157 have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on BPC-157?
While there are over 200 published studies on BPC-157, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source