PubMed
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias AJ, Perrone R, Grozio A, et al. Nat Rev Mol Cell Biol. 2021
Compare
NAD+ vs Semaglutide
Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.
Last reviewed . By the PeptIQ team.
Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
NAD+
96 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 2% · Mixed 98% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
197
Appetite
197
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Headache
66
Nausea
64
Injection site irritation
64
Self-reported dose per injection
Median bucket: 5+ mg · Most common: 5+ mg
Reports span 0.1 to ≥ 5 mg (open-ended top bucket)
0.1–0.2 mg
2
0.2–0.4 mg
17
0.4–0.6 mg
8
0.6–1 mg
1
1–2 mg
2
3–5 mg
2
5+ mg
165
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 95% said they felt similar to their last entry, 5% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 51 days · Based on 42 repeat reporters
Semaglutide
26 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 4% · Mixed 96% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Appetite
122
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Nausea
117
Self-reported dose per injection
Median bucket: 1–2 mg · Most common: 2–3 mg
Reports span 0 to ≥ 5 mg (open-ended top bucket)
0–0.01 mg
32
0.2–0.4 mg
5
0.4–0.6 mg
4
0.6–1 mg
9
1–2 mg
33
2–3 mg
34
5+ mg
5
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 78% said they felt similar to their last entry, 22% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 94 days · Based on 23 repeat reporters
Sources (16)
Published sources linked on the NAD+ and Semaglutide wiki pages.
- Wiki study page →Source
- Wiki study page →Source
PubMed
Safety and efficacy of NAD+ supplementation: a systematic review
Reiten OK, Wilvang MA, Mitchell SJ, et al. J Clin Invest. 2021
- Wiki study page →Source
PubMed
NAD+ intermediates: The biology and therapeutic potential
Yoshino J, Baur JA, Imai SI. Cell Metab. 2018
- Wiki study page →Source
ClinicalTrials.gov
NAD+ studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Bhasin S, Seals D, Migaud M, et al. Endocrine reviews. 2023
- Wiki study page →Source
PubMed
NAD⁺ in aging, metabolism, and neurodegeneration
Verdin E. Science (New York, N.Y.). 2015
- Wiki study page →Source
PubMed
NAD+ and sirtuins in aging and disease
Imai S, Guarente L. Trends in cell biology. 2014
- Wiki study page →Source
PubMed
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song Q, Zhou X, Xu K, et al. Advances in nutrition (Bethesda, Md.). 2023
- Wiki study page →Source
FDA Drug Label
WEGOVY (semaglutide) injection, for subcutaneous use - Prescribing Information
Novo Nordisk. FDA Drug Label. 2021
- Wiki study page →Source
FDA Drug Label
OZEMPIC (semaglutide) injection, for subcutaneous use - Prescribing Information
Novo Nordisk. FDA Drug Label. 2017
- Wiki study page →Source
PubMed
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
Wilding JPH, Batterham RL, Calanna S, et al. N Engl J Med. 2021
- Wiki study page →Source
ClinicalTrials.gov
Semaglutide obesity studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
Once-Weekly Semaglutide in Adolescents with Obesity.
Weghuber D, Barrett T, Barrientos-Pérez M, et al. N Engl J Med. 2022
- Wiki study page →Source
PubMed
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.
Kosiborod MN, Abildstrøm SZ, Borlaug BA, et al. N Engl J Med. 2023
- Wiki study page →Source
PubMed
Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss.
Wharton S, Calanna S, Davies M, et al. Diabetes Obes Metab. 2022
- Wiki study page →Source
PubMed
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. The New England journal of medicine. 2023