Peptides researched for
Dementia (cognitive decline)
Staying sharp as you get older
3 peptides · 6 studies
What people research this for
Many people want to protect their memory and thinking as they age, or are looking for answers for a parent or partner. Researchers have tested a few peptides for memory and for protecting brain cells. None of them is an approved dementia treatment.
Researched for
- Memory and thinking with age
- Protecting brain cells
- Mild memory problems
What the studies say so far
The evidence here is thin and uneven. Dihexa has only been tested in animals, mostly rodents in learning and memory tests. Semax has a small brain imaging study in people and no large dementia trial. Cerebrolysin has been used in clinics for decades and has the most human research, but reviews rate the quality of that research as mixed. No peptide on this page has been shown to slow or reverse dementia.
Peptides studied
Each peptide below has been studied in this area. The label shows how far that research has gone.
Dihexa
Early lab and animal researchAnimal study · 2 studies
Study note. Ang IV / Dihexa analog literature discusses learning and memory models, no established human dementia efficacy.
- The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases. (opens in a new tab)
Wright JW, Kawas LH, Harding JW · Progress in neurobiology · 2015 · PubMed
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies. (opens in a new tab)
Ho JK, Nation DA · Neuroscience and biobehavioral reviews · 2018 · PubMed
- The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases. (opens in a new tab)
Semax
Small early studies in peopleObservational study in people · 2 studies
Study note. Semax appears in connectomic and ischemia-related neurobiology papers; large dementia RCTs are lacking.
- Functional Connectomic Approach to Studying Selank and Semax Effects. (opens in a new tab)
Panikratova YR, Lebedeva IS, Sokolov OY · Doklady biological sciences · 2020 · PubMed
- Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period. (opens in a new tab)
Filippenkov IB, Remizova JA, Stavchansky VV · Genes · 2023 · PubMed
- Functional Connectomic Approach to Studying Selank and Semax Effects. (opens in a new tab)
Cerebrolysin
Mixed resultsResearch review · 2 studies
Study note. Long clinical-use reviews in cognitive impairment exist alongside low-certainty stroke meta-analyses, mixed overall quality.
- Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer's disease: 30 years of clinical use. (opens in a new tab)
Gavrilova SI, Alvarez A · Medicinal research reviews · 2021 · PubMed
- Cerebrolysin for acute ischaemic stroke. (opens in a new tab)
Ziganshina LE, Abakumova T, Vernay L · The Cochrane database of systematic reviews · 2017 · PubMed
- Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer's disease: 30 years of clinical use. (opens in a new tab)
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