PubMed
Gonadotropin-releasing hormone agonists and antagonists in assisted reproduction
Al-Inany et al., 2016
Hormonal & EndocrineFDA Approved / CompoundableA
Gonadorelin
GnRH / Factrel
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH), a 10-amino acid hypothalamic peptide. FDA-approved for diagnosing hypogonadotropic hypogonadism and evaluating pituitary-gonadal function. Widely used in men on testosterone replacement therapy (TRT) to maintain testicular size, fertility, and endogenous testosterone production by preventing HPG axis suppression. Available through compounding pharmacies.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 4
- Research grade
- A
- Experience
- 99
- Activity
- 74
Overall check-ins
Trackers & reports
Overview
About Gonadorelin
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH), a 10-amino acid hypothalamic peptide. FDA-approved for diagnosing hypogonadotropic hypogonadism and evaluating pituitary-gonadal function. Widely used in men on testosterone replacement therapy (TRT) to maintain testicular size, fertility, and endogenous testosterone production by preventing HPG axis suppression. Available through compounding pharmacies.
- Category
- Hormonal & Endocrine
- Regulatory status
- FDA Approved / Compoundable
- Also known as
- GnRH / Factrel
- Self-reports
- 25
Community
What 25 users report
25 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 97% · Mixed 3% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Libido
181
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Nausea
2
Injection site irritation
2
Headache
1
Self-reported dose per injection
Median bucket: 100–200 mcg · Most common: 100–200 mcg
Reports span 50–400 mcg
50–100
59
100–200
62
200–400
60
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 87% said they felt similar to their last entry, 13% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 235 days · Based on 23 repeat reporters
Research
Cited research (3)
Source
PubMed
Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis
Collado-Sole et al., 2026
PubMed
How to pause fertility
Moore, 2024
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Frequently asked
What do PeptIQ users report about Gonadorelin?
This page summarizes 25 anonymized self-reports from PeptIQ users who track Gonadorelin, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for Gonadorelin?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for Gonadorelin?
3 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is Gonadorelin safe to use?
This wiki does not assess safety or recommend use. Gonadorelin is listed as FDA Approved / Compoundable. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of Gonadorelin?
Research, primarily in animal models, suggests Gonadorelin may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of Gonadorelin?
Gonadorelin is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Gonadorelin as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of Gonadorelin?
The safety and effectiveness of Gonadorelin have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on Gonadorelin?
While there are over 200 published studies on Gonadorelin, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source