PubMed
Insulin-like growth factor-I and its binding proteins in sport and exercise medicine
Baxter RC. Endocr Rev. 2011
Compare
IGF-1 LR3 vs Ipamorelin
Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.
Last reviewed . By the PeptIQ team.
Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
IGF-1 LR3
30 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 97% · Mixed 3% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Recovery
171
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Water retention
5
Self-reported dose per injection
Median bucket: 50–100 mcg · Most common: 10–25 mcg
Reports span 0–200 mcg
0–10
1
10–25
60
25–50
1
50–100
53
100–200
56
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 96% said they felt similar to their last entry, 4% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 153 days · Based on 28 repeat reporters
Ipamorelin
102 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 98% · Mixed 2% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
236
Sleep
236
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Water retention
2
Headache
2
Self-reported dose per injection
Median bucket: 0.2–0.4 mg · Most common: 0.2–0.4 mg
Reports span 0.05 to ≥ 5 mg (open-ended top bucket)
0.05–0.1 mg
12
0.1–0.2 mg
63
0.2–0.4 mg
137
0.4–0.6 mg
22
5+ mg
2
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 98% said they felt similar to their last entry, 2% more positive, and 0% more negative.
Overall, repeat reporters leaned similar or mixed compared to their previous entry.
Median gap between entries: 51 days · Based on 44 repeat reporters
Sources (9)
Published sources linked on the IGF-1 LR3 and Ipamorelin wiki pages.
- Wiki study page →Source
- Wiki study page →Source
ClinicalTrials.gov
IGF-1 LR3 studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice
Engel MG, Narayan S, Cui MH, et al. Journal of Alzheimer's disease : JAD. 2025
- Wiki study page →Source
PubMed
Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration
Yavuz E, Sağır MS, Ercan A, et al. International journal of biological macromolecules. 2025
- Wiki study page →Source
PubMed
Ipamorelin, a new growth hormone-releasing peptide
Johansen PB, Nowak J, Skjaerbaek C, et al. Eur J Endocrinol. 2001
- Wiki study page →Source
PubMed
Growth hormone-releasing peptides: clinical applications
Ghigo E, Arvat E, Camanni F. Endocrine. 2008
- Wiki study page →Source
ClinicalTrials.gov
Ipamorelin growth hormone studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, et al. European journal of endocrinology. 1998
- Wiki study page →Source
PubMed
The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism
Lu Z, Ngan MP, Liu JYH, et al. Physiology & behavior. 2024