Review Article
GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes
Pickart L, Margolina A. Cosmetics. 2018
Compare
GHK-Cu vs Hexarelin
Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.
Last reviewed . By the PeptIQ team.
Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
GHK-Cu
120 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 3% · Mixed 97% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Mood
226
Recovery
226
Energy
1
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Injection site irritation
222
Self-reported dose per injection
Median bucket: 2–3 mg · Most common: 2–3 mg
Reports span 0 to ≥ 5 mg (open-ended top bucket)
0–0.01 mg
1
0.025–0.05 mg
16
0.2–0.4 mg
4
0.6–1 mg
1
1–2 mg
71
2–3 mg
87
3–5 mg
43
5+ mg
5
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 89% said they felt similar to their last entry, 11% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 46 days · Based on 45 repeat reporters
Hexarelin
24 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 97% · Mixed 3% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Recovery
143
Sleep
143
Energy
78
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Water retention
5
Self-reported dose per injection
Median bucket: 100–200 mcg · Most common: 100–200 mcg
Reports span 100–400 mcg
100–200
84
200–400
59
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 87% said they felt similar to their last entry, 13% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 148 days · Based on 23 repeat reporters
Sources (11)
Published sources linked on the GHK-Cu and Hexarelin wiki pages.
- Wiki study page →Source
- Wiki study page →Source
PubMed
GHK-Cu in wound healing and tissue regeneration
Pickart L. J Biomater Sci Polym Ed. 2008
- Wiki study page →Source
PubMed
GHK peptide as a natural modulator of multiple cellular pathways
Pickart L, Margolina A. Biomed Res Int. 2014
- Wiki study page →Source
ClinicalTrials.gov
GHK-Cu copper peptide studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Pickart L, Vasquez-Soltero JM, Margolina A. BioMed research international. 2015
- Wiki study page →Source
PubMed
Biomimetic Hydrogel Scaffolds with Copper Peptide-Functionalized RADA16 Nanofiber Improve Wound Healing in Diabetes
Yang X, Zhang Y, Huang C, et al. Macromolecular bioscience. 2022
- Wiki study page →Source
PubMed
Hexarelin, a synthetic growth hormone-releasing peptide, vs GHRH in GH-deficient adults
Ghigo E, Arvat E, Muccioli G, et al. Eur J Endocrinol. 1996
- Wiki study page →Source
PubMed
Hexarelin provides cardioprotective effects in rats
Bisi G, Podio V, Valetto MR, et al. Growth Horm IGF Res. 2001
- Wiki study page →Source
ClinicalTrials.gov
Hexarelin studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
We are ageing
Kolovou GD, Kolovou V, Mavrogeni S. BioMed research international. 2014
- Wiki study page →Source
PubMed
The cardiovascular action of hexarelin
Mao Y, Tokudome T, Kishimoto I. Journal of geriatric cardiology : JGC. 2014