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Collagen Peptides vs IGF-1 DES

Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.

Last reviewed . By the PeptIQ team.

Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
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Collagen Peptides

6 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 100% · Mixed 0% · Unfavorable overall 0%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Recovery
6
Mood
6

Self-reported dose per injection

Median bucket: 0–25 mcg · Most common: 0–25 mcg

Reports cluster around 0–25 mcg

0–25
6

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

Commonly stacked with

IGF-1 DES

2337 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 51% · Mixed 32% · Unfavorable overall 17%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Skin appearance
48
Appetite control
39
Energy
127
Mood
93
Focus
112

Most logged side effects

Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Headache
144
GI discomfort
118
Dizziness
92
Fatigue
89
Nausea
111

Self-reported dose per injection

Median bucket: 0.4–0.6 mg · Most common: 0.2–0.4 mg

Reports span 0.05–2 mg

0.05–0.1 mg
7
0.1–0.2 mg
15
0.2–0.4 mg
18
0.4–0.6 mg
14
0.6–1 mg
8
1–2 mg
2

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

Common discussion topics

timing21stacking19side effects17igf-1 des20

How repeat users are trending

Among repeat reporters, 61% said they felt similar to their last entry, 43% more positive, and 21% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 23 days · Based on 514 repeat reporters

Sources (10)

Published sources linked on the Collagen Peptides and IGF-1 DES wiki pages.

  1. PubMed

    Oral intake of specific bioactive collagen peptides reduces skin wrinkles and improves dermal matrix synthesis

    Proksch E, Schunck M, Zague V, et al. Skin Pharmacol Physiol. 2014

    Source
    Wiki study page →

  2. PubMed

    Collagen supplementation for osteoarthritis: a systematic review and meta-analysis

    García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, et al. Int Orthop. 2019

    Source
    Wiki study page →

  3. PubMed

    Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing

    Czajka A, Kania EM, Genovese L, et al. Nutrition research (New York, N.Y.). 2018

    Source
    Wiki study page →

  5. PubMed

    Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I

    Ballard FJ, Wallace JC, Francis GL, et al. Int J Biochem Cell Biol. 1996

    Source
    Wiki study page →

  6. PubMed

    Enhanced potency of truncated insulin-like growth factor-I (des(1-3)IGF-I) relative to IGF-I in lit/lit mice

    Gillespie C, Read LC, Bagley CJ, et al. J Endocrinol. 1990

    Source
    Wiki study page →

  7. PubMed

    In vivo actions of IGF analogues with poor affinities for IGFBPs: metabolic and growth effects in pigs of different ages and GH responsiveness

    Walton PE, Dunshea FR, Ballard FJ. Prog Growth Factor Res. 1995

    Source
    Wiki study page →

  8. PubMed

    IGF-I variants which bind poorly to IGF-binding proteins show more potent and prolonged hypoglycaemic action than native IGF-I in pigs and marmoset monkeys

    Tomas FM, Walton PE, Dunshea FR, et al. J Endocrinol. 1997

    Source
    Wiki study page →

  9. PubMed

    Insulin-like growth factor-I and its N-terminal modified analogues induce marked gut growth in dexamethasone-treated rats

    Read LC, Tomas FM, Howarth GS, et al. J Endocrinol. 1992

    Source
    Wiki study page →

  10. ClinicalTrials.gov

    des(1-3)IGF-1 / IGF-1 DES studies on ClinicalTrials.gov

    ClinicalTrials.gov. Clinical trial registry. 2024

    Source
    Wiki study page →

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