PubMed
Humanin: a novel mitochondrial-derived peptide that protects against cellular stress
Hashimoto et al., 2003
MitochondrialResearch OnlyB
Humanin
HN / Humanin-G (HNG)
Humanin is a 21-amino acid mitochondria-derived peptide encoded within the 16S rRNA region of the mitochondrial genome, discovered in 2001 from a cDNA library of Alzheimer's-resistant brain tissue. Research demonstrates neuroprotective, anti-apoptotic, and metabolic effects. Circulating humanin levels decline significantly with aging. Studied for Alzheimer's disease, diabetes, and cardiovascular protection. Research only.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 6
- Research grade
- B
- Experience
- 100
- Activity
- 75
Overall check-ins
Trackers & reports
Overview
About Humanin
Humanin is a 21-amino acid mitochondria-derived peptide encoded within the 16S rRNA region of the mitochondrial genome, discovered in 2001 from a cDNA library of Alzheimer's-resistant brain tissue. Research demonstrates neuroprotective, anti-apoptotic, and metabolic effects. Circulating humanin levels decline significantly with aging. Studied for Alzheimer's disease, diabetes, and cardiovascular protection. Research only.
- Category
- Mitochondrial
- Regulatory status
- Research Only
- Also known as
- HN / Humanin-G (HNG)
- Self-reports
- 6
Community
What 6 users report
6 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 100% · Mixed 0% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
6
Self-reported dose per injection
Median bucket: 2+ mg · Most common: 2+ mg
Reports span 1 to ≥ 2 mg (open-ended top bucket)
1–2 mg
2
2+ mg
4
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
Research
Cited research (4)
Source
PubMed
Humanin and the mitochondria in Alzheimer disease
Mitchell et al., 2015
PubMed
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
Hazafa et al., 2021
PubMed
Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders
Rochette et al., 2020
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Frequently asked
What do PeptIQ users report about Humanin?
This page summarizes 6 anonymized self-reports from PeptIQ users who track Humanin, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for Humanin?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for Humanin?
4 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is Humanin safe to use?
This wiki does not assess safety or recommend use. Humanin is listed as Research Only. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of Humanin?
Research, primarily in animal models, suggests Humanin may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of Humanin?
Humanin is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified Humanin as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of Humanin?
The safety and effectiveness of Humanin have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on Humanin?
While there are over 200 published studies on Humanin, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source