PubMed
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence
Anisimov VN, Khavinson VK, Popovich IG, et al. Biogerontology. 2003
Longevity & Anti-AgingResearch OnlyA
Epithalon
Epitalon / Epithalamin
Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin extracted from the pineal gland. Pioneered by Russian researcher Vladimir Khavinson, studies suggest it may stimulate telomerase activity and extend telomere length, regulate melatonin production, and normalize neuroendocrine system function. Mostly animal and limited human aging studies; not FDA-approved. It is typically reconstituted with bacteriostatic water and injected on its own during short 10–20 day cycles; there is no published same-syringe compatibility data for combining Epithalon with other peptides, so co-administration is best done as separate injections.
Last reviewed . First published . By the PeptIQ team.
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 15
- Research grade
- A
- Experience
- 56
- Activity
- 40
Overall check-ins
Trackers & reports
Overview
About Epithalon
Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin extracted from the pineal gland. Pioneered by Russian researcher Vladimir Khavinson, studies suggest it may stimulate telomerase activity and extend telomere length, regulate melatonin production, and normalize neuroendocrine system function. Mostly animal and limited human aging studies; not FDA-approved. It is typically reconstituted with bacteriostatic water and injected on its own during short 10–20 day cycles; there is no published same-syringe compatibility data for combining Epithalon with other peptides, so co-administration is best done as separate injections.
- Category
- Longevity & Anti-Aging
- Regulatory status
- Research Only
- Also known as
- Epitalon / Epithalamin
- Self-reports
- 37
Community
What 37 users report
37 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 3% · Mixed 97% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Energy
160
Sleep
160
Most logged side effects
Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Injection site irritation
155
Self-reported dose per injection
Median bucket: 2+ mg · Most common: 2+ mg
Reports span 0 to ≥ 2 mg (open-ended top bucket)
0–0.025 mg
4
0.2–0.4 mg
5
0.4–0.6 mg
14
1–2 mg
4
2+ mg
133
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
How repeat users are trending
Among repeat reporters, 86% said they felt similar to their last entry, 14% more positive, and 0% more negative.
Overall, repeat reporters leaned more positive than their previous entry.
Median gap between entries: 32 days · Based on 35 repeat reporters
Research
Sources (13)
- Wiki study page →Source
- Wiki study page →Source
PubMed
Epitalon peptide induces telomerase activity in human somatic cells
Khavinson VK, Bondarev IE, Butyugov AA. Bull Exp Biol Med. 2003
- Wiki study page →Source
PubMed
Peptide bioregulation of aging: results of a 15-year study
Khavinson VK. Bull Exp Biol Med. 2002
- Wiki study page →Source
ClinicalTrials.gov
Epitalon / epithalon studies on ClinicalTrials.gov
ClinicalTrials.gov. Clinical trial registry. 2024
- Wiki study page →Source
PubMed
Peptide promotes overcoming of the division limit in human somatic cell
Khavinson VKh, Bondarev IE, Butyugov AA, et al. Bulletin of experimental biology and medicine. 2004
- Wiki study page →Source
PubMed
Reparative effect of epithalon on pineal gland ultrastructure in gamma-irradiated rats
Khavinson VK, Yakovleva ND, Popuchiev VV, et al. Bull Exp Biol Med. 2001
- Wiki study page →Source
PubMed
Effect of pineal peptides on neuroendocrine system after pinealectomy
Khavinson VKh, Kvetnoi IM, Popuchiev VV, et al. Arkh Patol. 2001
- Wiki study page →Source
PubMed
Modulating effects of epithalamin and epithalon on the functional morphology of the spleen in old pinealectomized rats
Khavinson VK, Konovalov SS, Yuzhakov VV, et al. Bull Exp Biol Med. 2001
- Wiki study page →Source
PubMed
Aging of the pineal gland
Khavinson VKh, Golubev AG. Adv Gerontol. 2002
- Wiki study page →Source
PubMed
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Khavinson V, Razumovsky M, Trofimova S, et al. Neuro Endocrinol Lett. 2002
- Wiki study page →Source
Review Article
Peptides and Ageing
Khavinson VKh. Neuro Endocrinol Lett. 2002
- Wiki study page →Source
PubMed
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Khavinson V, Diomede F, Mironova E, et al. Molecules. 2020
- Wiki study page →Source
Review Article
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF, Lee SJ, Seeds WA. J Am Acad Orthop Surg Glob Res Rev. 2026
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Frequently asked
What do PeptIQ users report about Epithalon?
This page summarizes 37 anonymized self-reports from PeptIQ users who track Epithalon, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for Epithalon?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for Epithalon?
13 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is Epithalon safe to use?
This wiki does not assess safety or recommend use. Epithalon is listed as Research Only. Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of Epithalon?
This wiki summarizes observational community reports and linked citations for Epithalon. It does not assert therapeutic benefits. See the sources list on this page and the educational profile for Epithalon for study-level context — not medical advice.
What is the legal status of Epithalon?
Epithalon is listed in PeptIQ as Research Only. Regulatory status varies by jurisdiction and can change. This wiki does not provide legal advice; check current FDA and local rules and talk with a licensed clinician or counsel for personal decisions.
What are the known or theoretical side effects and risks of Epithalon?
Safety data quality for Epithalon varies widely by compound and study design. PeptIQ does not establish a risk profile here. Review primary literature, product labeling where applicable, and clinician guidance. Community self-reports are not a substitute for clinical evidence.
What is the current state of research on Epithalon?
This page links 13 sources for Epithalon. Evidence maturity differs by application — some peptides have large human programs, others are mostly preclinical. Treat citation counts as literature volume, not proof of efficacy.