PubMed
Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)
Davalos et al., 2012
Neurological & CognitiveSupplement / Drug (region-dependent)C
CDP-Choline
Citicoline
Choline donor and nootropic compound used for cognitive and neuro-support protocols (non-peptide).
Observational report only — live community data. Not medical advice. Does not recommend doses, protocols, or treatments.
- Studies cited
- 5
- Research grade
- C
- Experience
- 100
- Activity
- 67
Overall check-ins
Trackers & reports
Overview
About CDP-Choline
Choline donor and nootropic compound used for cognitive and neuro-support protocols (non-peptide).
- Category
- Neurological & Cognitive
- Regulatory status
- Supplement / Drug (region-dependent)
- Also known as
- Citicoline
- Self-reports
- 6
Community
What 6 users report
6 community reports
Overall experience
From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.
Favorable 100% · Mixed 0% · Unfavorable overall 0%
Most reported benefits
Benefits users selected when logging a favorable or mixed check-in.
Cognition
6
Self-reported dose per injection
Median bucket: 2+ mg · Most common: 2+ mg
Reports span 2 to ≥ 2 mg (open-ended top bucket)
2+ mg
6
Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.
Commonly stacked with
Research
Cited research (4)
Source
PubMed
Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT)
Zafonte et al., 2012
ClinicalTrials.gov
International Citicoline Trial on Acute Stroke (ICTUS) (NCT00331890)
ClinicalTrials.gov, 2006
ClinicalTrials.gov
Citicoline Brain Injury Treatment Trial (COBRIT) (NCT00545662)
ClinicalTrials.gov, 2007
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Frequently asked
What do PeptIQ users report about CDP-Choline?
This page summarizes 6 anonymized self-reports from PeptIQ users who track CDP-Choline, including commonly reported effects and co-tracked peptides. These are observational patterns, not clinical outcomes.
How do side effects relate to overall experience for CDP-Choline?
PeptIQ separates overall check-in ratings (favorable, mixed, or unfavorable) from logged side effects like nausea or fatigue. Users often report benefits and side effects in the same check-in — a high experience score does not mean zero side effects were noted.
What research is cited for CDP-Choline?
4 sources are linked on this page, including PubMed articles, clinical trial registries, and FDA labels where applicable. Citations describe published research — not recommendations.
Is CDP-Choline safe to use?
This wiki does not assess safety or recommend use. CDP-Choline is listed as Supplement / Drug (region-dependent). Consult a licensed clinician for personal medical decisions.
What are the purported benefits and uses of CDP-Choline?
Research, primarily in animal models, suggests CDP-Choline may have a wide range of therapeutic potentials due to its ability to promote angiogenesis (formation of new blood vessels), stimulate collagen synthesis, and modulate inflammatory responses.
SourceWhat is the legal status of CDP-Choline?
CDP-Choline is not approved by the FDA for any human use. There is no legal basis for selling it as a drug, food, or dietary supplement in the United States. The FDA has classified CDP-Choline as a Category 2 bulk drug substance, which explicitly prohibits licensed compounding pharmacies from using it in compounded medications.
SourceWhat are the known or theoretical side effects and risks of CDP-Choline?
The safety and effectiveness of CDP-Choline have not been thoroughly evaluated in humans through rigorous clinical trials. This lack of human data means that safe dosages, short-term side effects, and long-term health consequences are largely unknown.
SourceWhat is the current state of research on CDP-Choline?
While there are over 200 published studies on CDP-Choline, the vast majority are animal or in vitro (cell) studies. These preclinical studies consistently show positive results across various tissue types. However, there is a significant lack of comprehensive human clinical trial data.
Source