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Selank vs Semax

Side-by-side observational reports from PeptIQ users. This compares self-reported patterns — not clinical head-to-head trials.

Last reviewed . By the PeptIQ team.

360 users report co-tracking this pair (12% of Selank trackers also track Semax).

Observational reporting only — not medical advice. Does not recommend doses, protocols, or treatments.
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Selank

57 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 3% · Mixed 97% · Unfavorable overall 0%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Mood
184
Recovery
184

Most logged side effects

Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Injection site irritation
94
Fatigue
85

Self-reported dose per injection

Median bucket: 0.2–0.4 mg · Most common: 0.2–0.4 mg

Reports span 0.1 to ≥ 5 mg (open-ended top bucket)

0.1–0.2 mg
3
0.2–0.4 mg
96
0.4–0.6 mg
76
0.6–1 mg
5
1–2 mg
2
5+ mg
2

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

How repeat users are trending

Among repeat reporters, 86% said they felt similar to their last entry, 14% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 54 days · Based on 35 repeat reporters

Semax

74 community reports

Overall experience

From check-in ratings — separate from side effects logged below. Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Favorable 97% · Mixed 3% · Unfavorable overall 0%

Most reported benefits

Benefits users selected when logging a favorable or mixed check-in.

Mood
197
Cognition
196
Energy
1

Most logged side effects

Side effects are logged separately from overall experience. A favorable check-in can still include nausea, fatigue, or injection-site reactions.

Injection site irritation
5

Self-reported dose per injection

Median bucket: 0.2–0.4 mg · Most common: 0.2–0.4 mg

Reports span 0.1 to ≥ 5 mg (open-ended top bucket)

0.1–0.2 mg
37
0.2–0.4 mg
71
0.4–0.6 mg
41
0.6–1 mg
45
1–2 mg
2
5+ mg
1

Anonymized self-reports from PeptIQ users — not prescribing guidance. Buckets group similar logged amounts; open-ended top buckets mean “at least” that dose.

How repeat users are trending

Among repeat reporters, 92% said they felt similar to their last entry, 8% more positive, and 0% more negative.

Overall, repeat reporters leaned more positive than their previous entry.

Median gap between entries: 46 days · Based on 37 repeat reporters

Sources (12)

Published sources linked on the Selank and Semax wiki pages.

  1. PubMed

    Selank and short peptides regulate expression of inflammatory genes

    Ershov FI, Uchakin PN, Ershova OV. Bull Exp Biol Med. 2017

    Source
    Wiki study page →

  2. PubMed

    Selank, a tuftsin analogue, demonstrates anxiolytic activity

    Seredenin SB, Kozlovskaya MM. Bull Exp Biol Med. 2008

    Source
    Wiki study page →

  5. PubMed

    Functional Connectomic Approach to Studying Selank and Semax Effects

    Panikratova YR, Lebedeva IS, Sokolov OY, et al. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2020

    Source
    Wiki study page →

  6. PubMed

    Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats

    Konstantinopolsky MA, Chernyakova IV, Kolik LG. Bulletin of experimental biology and medicine. 2022

    Source
    Wiki study page →

  7. PubMed

    Semax, an analog of ACTH(4-7), regulates expression of immune response genes

    Dmitrieva VG, Povarova OV, Skvortsova VI, et al. Mol Genet Genomics. 2013

    Source
    Wiki study page →

  8. PubMed

    Semax, a synthetic analog of ACTH, shows neuroprotective properties

    Ashmarin IP, Nezavibatko VN, Levitskaya NG, et al. Neurosci Res. 2006

    Source
    Wiki study page →

  9. PubMed

    Semax affects BDNF expression and neuroplasticity

    Dolotov OV, Karpenko EA, Inozemtseva LS, et al. J Neurochem. 2008

    Source
    Wiki study page →

  11. PubMed

    Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases

    Giri S, Chandra P. Neuropeptides. 2025

    Source
    Wiki study page →

  12. PubMed

    [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]

    Gusev EI, Martynov MY, Kostenko EV, et al. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018

    Source
    Wiki study page →

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