actually work? What ones are overhyped? And what ones should you absolutely avoid at all costs? Stay tuned cuz I'm going to tell you everything I think as a medical doctor who's interested in peptides. So today I'm going to rank every single peptide based on their potential from S to F. And some of these rankings are going to make people angry, but let's go. >> [music] >> So starting off with the F tier, these are the ones that you should avoid in my opinion. First up is melanotan II. Yes, it's a peptide that's supposed to stimulate your melanocytes and give you a tan without any sun exposure. And it's very popular in the looks maxing space. But there are some serious side effects which makes me think that it's acting on other parts of your brain as well and not just on the part that's going to stimulate the melanin production. Things like nausea, facial flushing, dizziness, erections in men. So these make me think that it's acting on different parts of your limbic system. I'll get into it in another video at some point. But despite what the influencers are saying, this isn't just giving you a tan, it's doing something else to you. Now obviously, if you're stimulating tanning, you're stimulating moles. And whenever you stimulate a mole, you've got an increased risk of that turning into a melanoma. It also makes moles look really funny. So when we look at melanomas, we see moles that change really quickly, which is what melanotan is doing to your moles anyway. So you might get false diagnoses. So because I think it's acting on different parts of your brain that it's supposed to, and because it does weird things moles, it's a big avoid from me. If you're really desperate to get a tan, I would always say stick to fake tan. But there's melanotan one which might be a bit safer, but you need to do your own research on that one. So let's move on to the D tier. These are peptides that I think are overhyped and under promise on what influencers tell you that they're going to do. So the first one is selank. I've heard so much about this, that it's great for anxiety. When you actually look at the research, it all comes out of Russia and it's all a bit shady if I'm honest. And there's zero Western data on it. It's funny though because people who believe in it don't seem to have a problem with studies from Russia from the '80s, which I find a bit bizarre. Don't get me wrong, the theory behind it is interesting. It just isn't backed up in the studies. And I wouldn't waste your time or your money looking into it. That's my opinion. Then there's AOD 9604, which is marketed as a fat loss peptide. And basically it's a little fragment of growth hormone. And the data that's out there on it is extremely weak. This has just been marketed really well. And sometimes you've just got to put your hands up and say people are marketing this fantastically, but the data doesn't back it up. I'd avoid it. Okay, now we move to the C tier. There's PT 141, which is also known as bremelanotide. And this does have FDA approval for women with low sex drive. But for men using it, there is no evidence. It's all anecdotes. Like all my friends took it and he was great. So it would work for some people and do nothing for others. I would save your money. I don't think it's worth it. Then we get into the growth hormone secretagogues like ipamorelin. Again, I always get a little bit wary of anything that's stimulating IGF. As we know, increased IGF levels can stimulate tumors. But if you were being sensible and measuring your IGF-1 levels on something like this, then you could potentially minimize the risk. But people just don't do that. But I just don't think it's worth it because you have to take it often. You have to be consistent with it. And I think that people in general are just not that good at taking these things. So for me, it's not something that I'd be recommending people to take, especially not on its own. Okay, so now we get on to the B tier peptides. These are the things that have actually got some decent research behind them. But again, remember, I'm not suggesting that you take any of these. You need to do your own research. And if you still feel like you want to do it at the end of all your research, then it's your body, it's your call. There's CGC 1295, which again is another growth hormone secretagogue. Similar issues I have when it comes to stimulating IGF-1. Some people stack that with ipamorelin that we were speaking about earlier. But I think this is in the B tier for me because it takes time to work and you have to be consistent with it. And most people just aren't. Also in the B category, I put thymosin alpha one, which is supposed to do some immune modulation. And there have been over 200 publications on it since 2001. It was really a kind of post-COVID thing that stimulated a lot of interest in it. For the average person, I'm not really sure where I see the benefits. For somebody who's having immune issues, it might be slightly more appealing. But for your average person, I would say it's probably not worth it. And also in the B tier, I'm going to put semaglutide. And you've probably heard that as Ozempic or Wegovy. And the reason I'm putting it as a B tier is because it works incredibly well for weight loss, but it only hits one receptor. And there are new variations of these types of medicines coming out that hit two or three receptors. Watch my other video to find out about that. And so I think it's the equivalent of something being like an iPhone 12, but you've already got the iPhone 15 and then 17 coming out. It's still good and worth thinking about, but there's better alternatives out there. So now we're getting on to the A tier. And these are peptides that I think have the potential, when they've gone through the full research, to really be effective with predictable results and hopefully minimal side effects. So in here we've got things like BPC 157. I've done a full video on that already. There are over 180 PubMed publications on BPC 157. Where it looks most effective is for tissue repair and some evidence for gut healing. Guys like Joe Rogan and Andrew Huberman talk about all the time. I don't really give much weight to what they say. I just tend to look at the data and be objective. And I don't think you should be swayed by what an influencer is saying as to whether you take something or not. My only issue, as I say in my video about BPC 157, is that it does have the potential to stimulate angiogenesis via that VEGF1 pathway. And that's something that you do need to know before you start taking something like BPC 157 because you need to know the risks, the benefits, and everything else in between. You can't just hear that it's a miracle cure and it's going to help you with everything. There are potential downsides, and that's why when things go through medical trials, we work out is it truly safe or not. But we're not there yet. So then there's TB 500. Again, you've probably heard of this. People tend to stack BPC 157 with TB 500. So TB 500 has similar healing properties to BPC 157. It works just on a slightly different pathway. All the risks that I talk about with BPC 157 can be applied to TB 500. Okay, the last one in the B tier is epithalon. Now I love reading about epithalon because there's nothing like it on the market anywhere. And it looks like something that seems very futuristic in medicine. So it's been researched for the last 20 years. And the way that it's supposed to act is on telomere extension. We know that as we get older, our telomeres shorten. And the longevity space they love this because they see it as being a way of reversing that cellular aging process. So if you're looking for a specific anti-aging peptide, then epithalon might be something to look into. Again, no long-term human data on it. This is all based on preclinical data. But again, if you've got the risk appetite to take something like this, then do all the research you can before you make that decision. So now we're on to the S tier. If you've made it this far and you like these type of videos, give me a follow. So in at number three on the S tier, we have tirzepatide or Mounjaro as it's called. It works on two receptors. It works on GLP1 and it works on GIP. And for weight loss, it is a real game changer. In the phase three clinical trials, people who took it lost on average 22.5% of their body weight, which is incredible. So if it's weight loss that's your primary goal, Mounjaro or tirzepatide, it's FDA approved, it's out there, it's probably your best bet. Number two is GHK-Cu. And remember, I've done a video on GHK-Cu which has had over 58,000 views so far. If you're interested in it, go and watch that. Learn all you need to know about it before you start buying something off the internet. So this is probably the most researched peptide that's been used for skin rejuvenation and anti-aging and collagen production. It also promotes elastin in your skin. And if you look at my video on GHK-Cu, I talk about how it actually works, which is really incredible. Firstly, putting it on your skin is completely safe and you get really good results. But a lot of people seem to be just injecting it, which again, each to your own. But remember, injecting GHK-Cu might help in the skin cells and the cells that you want to repair, but we don't know what it does to other cells around your body. There isn't that long-term data. But again, that's up for you to decide. If you think it's worth taking the risk, then go for it. Number one on the S list, and it is the peptide that's blown everyone away. And it is that triple G, it's retatrutide. And I know it's not FDA approved yet, but in the phase two clinical trials, people lost on average 24.2% of their body weight. Incredible. And even after the study stopped, people still continued to lose weight. They didn't plateau like they do in some of the other weight loss medicines, which is genuinely incredible. Remember, it acts on three receptors. You've got the GLP1, the GIP, and it acts on the glucagon receptor as well. I've done a full video on reta if you're really interested. But if the phase three trials confirm what we've seen so far, this is genuinely going to be the most important peptide of the decade. Not only for weight loss, for things like fatty liver disease as well. So that's my complete list. And remember, I'm going off of the potential. These peptides are not approved, but I think it's important that you get all the information before you make a decision about whether you want to take them or not. And I know some of you are going to disagree with where I put things on the list, but I want to hear from you. Drop a comment below if you had a different idea and tell me what I got wrong. And if you want a deep dive into any of the specific peptides that I've spoken about, I've done individual videos on them. Go and check out my channel. Educate yourself as much as you can. Don't just listen to fitness and wellness influencers because they don't tell you the potential downside. At least if you watch my videos, you see it all. You see the good, the bad, and the ugly, and you can make a truly informed decision because for me, that's the most important thing. Until next time, see you later.